Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models
Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Mutations in the glucocerebrosidase gene (GBA) confer a heightened risk of developing Parkinson’s disease (PD) and other synucleinopathies, resulting in a lower age of onset and exacerbating disease progression. However, the precise mechanisms by which mutations in GBA increase PD risk and accelerate its progression remain unclear. Here, we investi...
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Full title
Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5347608
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5347608
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1616152114
