ProNGF, but Not NGF, Switches from Neurotrophic to Apoptotic Activity in Response to Reductions in T...
ProNGF, but Not NGF, Switches from Neurotrophic to Apoptotic Activity in Response to Reductions in TrkA Receptor Levels
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Publisher
Switzerland: MDPI
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Language
English
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Publisher
Switzerland: MDPI
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Nerve growth factor (NGF) promotes the survival and differentiation of neurons. NGF is initially synthesized as a precursor, proNGF, which is the predominant form in the central nervous system. NGF and proNGF bind to TrkA/p75NTR to mediate cell survival and to sortilin/p75NTR to promote apoptosis. The ratio of TrkA to p75NTR affects whether proNGF...
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Full title
ProNGF, but Not NGF, Switches from Neurotrophic to Apoptotic Activity in Response to Reductions in TrkA Receptor Levels
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5372615
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5372615
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ISSN
1422-0067
E-ISSN
1422-0067
DOI
10.3390/ijms18030599
