Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas
Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas
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Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Contents
Mutations in the isocitrate dehydrogenase genes IDH1 and IDH2 are among the first genetic alterations observed during the development of lower-grade glioma (LGG). LGG-associated IDH mutations confer gain-of-function activity by converting α-ketoglutarate to the oncometabolite R-2-hydroxyglutarate (2HG). Clinical samples and gene expression data fro...
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Full title
Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5373859
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5373859
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI90644
