Break-induced telomere synthesis underlies alternative telomere maintenance
Break-induced telomere synthesis underlies alternative telomere maintenance
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Homology-directed DNA repair is essential for genome maintenance through templated DNA synthesis. Alternative lengthening of telomeres (ALT) necessitates homology-directed DNA repair to maintain telomeres in about 10–15% of human cancers. How DNA damage induces assembly and execution of a DNA replication complex (break-induced replisome) at telomer...
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Full title
Break-induced telomere synthesis underlies alternative telomere maintenance
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5384111
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5384111
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ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/nature20099
