Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1...
Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
The ubiquitin–proteasome system (UPS) and macroautophagy (autophagy) are central to normal proteostasis and interdependent in that autophagy is known to compensate for the UPS to alleviate ensuing proteotoxic stress that impairs cell function. UPS and autophagy dysfunctions are believed to have a major role in the pathomechanisms of neurodegenerati...
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Full title
Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5386360
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5386360
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/cddis.2016.443
