Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice
Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice
About this item
Full title
Author / Creator
Sok, Devin , Briney, Bryan , Jardine, Joseph G. , Kulp, Daniel W. , Menis, Sergey , Pauthner, Matthias , Wood, Andrew , Lee, E-Chiang , Le, Khoa M. , Jones, Meaghan , Ramos, Alejandra , Kalyuzhniy, Oleksandr , Adachi, Yumiko , Kuhitz, Michael , MacPherson, Skye , Bradley, Allan , Friedrich, Glenn A. , Schief, William R. and Burton, Dennis R.
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
A major obstacle to a broadly neutralizing antibody (bnAb)-based HIV vaccine is the activation of appropriate cell precursors. Germline-targeting immunogens must be capable of priming rare bnAb precursors in the physiological setting. We tested the ability of the VRCOl-class bnAb germline-targeting immunogen eOD-GT8 60mer (60-subunit self-assemblin...
Alternative Titles
Full title
Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice
Authors, Artists and Contributors
Author / Creator
Briney, Bryan
Jardine, Joseph G.
Kulp, Daniel W.
Menis, Sergey
Pauthner, Matthias
Wood, Andrew
Lee, E-Chiang
Le, Khoa M.
Jones, Meaghan
Ramos, Alejandra
Kalyuzhniy, Oleksandr
Adachi, Yumiko
Kuhitz, Michael
MacPherson, Skye
Bradley, Allan
Friedrich, Glenn A.
Schief, William R.
Burton, Dennis R.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5404394
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5404394
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aah3945
