Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors
Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors
About this item
Full title
Author / Creator
Davidson, Shawn M , Jonas, Oliver , Keibler, Mark A , Hou, Han Wei , Luengo, Alba , Mayers, Jared R , Wyckoff, Jeffrey , Del Rosario, Amanda M , Whitman, Matthew , Chin, Christopher R , Condon, Kendall J , Lammers, Alex , Kellersberger, Katherine A , Stall, Brian K , Stephanopoulos, Gregory , Bar-Sagi, Dafna , Han, Jongyoon , Rabinowitz, Joshua D , Cima, Michael J , Langer, Robert and Vander Heiden, Matthew G
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Using a device implanted in KRAS-driven pancreatic tumors, authors demonstrate that cancer cells incorporate proteins in their microenvironment as a source of amino acids. This work provides a novel approach to study tumor metabolism that could be applied with therapeutic purposes.
Mammalian tissues rely on a variety of nutrients to support thei...
Alternative Titles
Full title
Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors
Authors, Artists and Contributors
Author / Creator
Jonas, Oliver
Keibler, Mark A
Hou, Han Wei
Luengo, Alba
Mayers, Jared R
Wyckoff, Jeffrey
Del Rosario, Amanda M
Whitman, Matthew
Chin, Christopher R
Condon, Kendall J
Lammers, Alex
Kellersberger, Katherine A
Stall, Brian K
Stephanopoulos, Gregory
Bar-Sagi, Dafna
Han, Jongyoon
Rabinowitz, Joshua D
Cima, Michael J
Langer, Robert
Vander Heiden, Matthew G
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5407288
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5407288
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.4256
