Protease-activated receptor-1 inhibits proliferation but enhances leukemia stem cell activity in acu...
Protease-activated receptor-1 inhibits proliferation but enhances leukemia stem cell activity in acute myeloid leukemia
About this item
Full title
Author / Creator
Goyama, S , Shrestha, M , Schibler, J , Rosenfeldt, L , Miller, W , O’Brien, E , Mizukawa, B , Kitamura, T , Palumbo, J S and Mulloy, J C
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Eradication of leukemia stem cells (LSCs) is the ultimate goal of treating acute myeloid leukemia (AML). We recently showed that the combined loss of
Runx1/Cbfb
inhibited the development of MLL-AF9-induced AML. However, c-Kit
+
/Gr-1
−
cells remained viable in
Runx1/Cbfb
-deleted cells, indicating that suppressing RUNX activ...
Alternative Titles
Full title
Protease-activated receptor-1 inhibits proliferation but enhances leukemia stem cell activity in acute myeloid leukemia
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5418093
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5418093
Other Identifiers
ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/onc.2016.416
