Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human ce...
Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells
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Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Cellular senescence is a tumour-suppressor mechanism that is triggered by cancer-initiating or promoting events in mammalian cells. The molecular underpinnings for this stable arrest involve transcriptional repression of proliferation-promoting genes regulated by the retinoblastoma (RB1)/E2F repressor complex. Here, we demonstrate that AGO2, RB1 an...
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Full title
Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5423543
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5423543
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb2443
