Topological defects in epithelia govern cell death and extrusion
Topological defects in epithelia govern cell death and extrusion
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
By modelling epithelial cells as active nematic liquid crystals, stresses induced at the sites of topological defects are found to be the primary drivers of extrusion and cell death.
A functional role for topological defects in epithelial monolayers
Epithelial monolayers remove excess cells by extrusion. Benoit Ladoux and colleagues now repor...
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Topological defects in epithelia govern cell death and extrusion
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5439518
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5439518
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature21718