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Topological defects in epithelia govern cell death and extrusion

Topological defects in epithelia govern cell death and extrusion

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5439518

Topological defects in epithelia govern cell death and extrusion

About this item

Full title

Topological defects in epithelia govern cell death and extrusion

Publisher

London: Nature Publishing Group UK

Journal title

Nature (London), 2017-04, Vol.544 (7649), p.212-216

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

By modelling epithelial cells as active nematic liquid crystals, stresses induced at the sites of topological defects are found to be the primary drivers of extrusion and cell death.
A functional role for topological defects in epithelial monolayers
Epithelial monolayers remove excess cells by extrusion. Benoit Ladoux and colleagues now repor...

Alternative Titles

Full title

Topological defects in epithelia govern cell death and extrusion

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5439518

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5439518

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/nature21718

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