A conserved NAD⁺ binding pocket that regulates protein-protein interactions during aging
A conserved NAD⁺ binding pocket that regulates protein-protein interactions during aging
About this item
Full title
Author / Creator
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
United States: American Association for the Advancement of Science
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More information
Scope and Contents
Contents
DNA repair is essential for life, yet its efficiency declines with age for reasons that are unclear. Numerous proteins possess Nudix homology domains (NHDs) that have no known function. We show that NHDs are NAD⁺ (oxidized form of nicotinamide adenine dinucleotide) binding domains that regulate protein-protein interactions. The binding of NAD⁺ to t...
Alternative Titles
Full title
A conserved NAD⁺ binding pocket that regulates protein-protein interactions during aging
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5456119
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5456119
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aad8242
