Mutations in the CCND1 and CCND2 genes are frequent events in adult patients with t(8;21)(q22;q22) a...
Mutations in the CCND1 and CCND2 genes are frequent events in adult patients with t(8;21)(q22;q22) acute myeloid leukemia
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Author / Creator
Eisfeld, A-K , Kohlschmidt, J , Schwind, S , Nicolet, D , Blachly, J S , Orwick, S , Shah, C , Bainazar, M , Kroll, K W , Walker, C J , Carroll, A J , Powell, B L , Stone, R M , Kolitz, J E , Baer, M R , de la Chapelle, A , Mrózek, K , Byrd, J C and Bloomfield, C D
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Core-binding factor acute myeloid leukemia (CBF-AML) is defined by the presence of either t(8;21)(q22;q22)/
RUNX1-RUNX1T1
or inv(16)(p13.1q22)/t(16;16)(p13.1;q22)/
CBFB-MYH11
. The resulting fusion genes require a ‘second hit’ to initiate leukemogenesis. Mutation assessment of 177 adults with CBF-AML, including 68 with t(8;21) and 109 w...
Alternative Titles
Full title
Mutations in the CCND1 and CCND2 genes are frequent events in adult patients with t(8;21)(q22;q22) acute myeloid leukemia
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5462855
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5462855
Other Identifiers
ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/leu.2016.332
