Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease
Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease
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Author / Creator
Pillai, Padmini S. , Molony, Ryan D. , Martinod, Kimberly , Dong, Huiping , Pang, Iris K. , Tal, Michal C. , Solis, Angel G. , Bielecki, Piotr , Mohanty, Subhasis , Trentalange, Mark , Homer, Robert J. , Flavell, Richard A. , Wagner, Denisa D. , Montgomery, Ruth R. , Shaw, Albert C. , Staeheli, Peter and Iwasaki, Akiko
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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Publisher
United States: American Association for the Advancement of Science
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Contents
Influenza A virus (IAV) causes up to half a million deaths worldwide annually, 90% of which occur in older adults. We show that IAV-infected monocytes from older humans have impaired antiviral interferon production but retain intact inflammasome responses. To understand the in vivo consequence, we used mice expressing a functional Mx gene encoding...
Alternative Titles
Full title
Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5465864
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5465864
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aaf3926
