Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels
Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels
About this item
Full title
Author / Creator
Hadden, William J. , Young, Jennifer L. , Holle, Andrew W. , McFetridge, Meg L. , Kim, Du Yong , Wijesinghe, Philip , Taylor-Weiner, Hermes , Wen, Jessica H. , Lee, Andrew R. , Bieback, Karen , Vo, Ba-Ngu , Sampson, David D. , Kennedy, Brendan F. , Spatz, Joachim P. , Engler, Adam J. and Choi, Yu Suk
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences
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More information
Scope and Contents
Contents
The spatial presentation of mechanical information is a key parameter for cell behavior. We have developed a method of polymerization control in which the differential diffusion distance of unreacted cross-linker and monomer into a prepolymerized hydrogel sink results in a tunable stiffness gradient at the cell–matrix interface. This simple, low-co...
Alternative Titles
Full title
Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5465928
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5465928
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1618239114
