Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
About this item
Full title
Author / Creator
Pauken, Kristen E. , Sammons, Morgan A. , Odorizzi, Pamela M. , Manne, Sasikanth , Godec, Jernej , Khan, Omar , Drake, Adam M. , Chen, Zeyu , Sen, Debattama R. , Kurachi, Makoto , Barnitz, R. Anthony , Bartman, Caroline , Bengsch, Bertram , Huang, Alexander C. , Schenkel, Jason M. , Vahedi, Golnaz , Haining, W. Nicholas , Berger, Shelley L. and Wherry, E. John
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
United States: American Association for the Advancement of Science
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More information
Scope and Contents
Contents
Blocking Programmed Death-1 (PD-1) can reinvigorate exhausted CD8 Tcells (TEX) and improve control of chronic infections and cancer. However, whether blocking PD-1 can reprogram TEX into durable memory Tcells (TMEM) is unclear. We found that reinvigoration of TEX in mice by PD-L1 blockade caused minimal memory development. After blockade, reinvigor...
Alternative Titles
Full title
Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
Authors, Artists and Contributors
Author / Creator
Sammons, Morgan A.
Odorizzi, Pamela M.
Manne, Sasikanth
Godec, Jernej
Khan, Omar
Drake, Adam M.
Chen, Zeyu
Sen, Debattama R.
Kurachi, Makoto
Barnitz, R. Anthony
Bartman, Caroline
Bengsch, Bertram
Huang, Alexander C.
Schenkel, Jason M.
Vahedi, Golnaz
Haining, W. Nicholas
Berger, Shelley L.
Wherry, E. John
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5484795
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5484795
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aaf2807
