PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator...
PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D
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Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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United States: American Association for the Advancement of Science
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Contents
Activating mutations in PIK3CA, the gene encoding phosphoinositide-(3)-kinase α (PI3Kα), are frequently found in estrogen receptor (ER)–positive breast cancer. PI3Kα inhibitors, now in late-stage clinical development, elicit a robust compensatory increase in ER-dependent transcription that limits therapeutic efficacy. We investigated the chromatin-...
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Full title
PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5485411
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5485411
Other Identifiers
ISSN
0036-8075,1095-9203
E-ISSN
1095-9203
DOI
10.1126/science.aah6893
