Optogenetic control of mitochondrial metabolism and Ca2+ signaling by mitochondria-targeted opsins
Optogenetic control of mitochondrial metabolism and Ca2+ signaling by mitochondria-targeted opsins
About this item
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Author / Creator
Tkatch, Tatiana , Greotti, Elisa , Baranauskas, Gytis , Pendin, Diana , Roy, Soumitra , Nita, Luliaoana I. , Wettmarshausen, Jennifer , Prigge, Matthias , Yizhar, Ofer , Shirihai, Orian S. , Fishman, Daniel , Hershfinkel, Michal , Fleidervish, Ilya A. , Perocchi, Fabiana , Pozzan, Tullio and Sekler, Israel
Publisher
National Academy of Sciences
Journal title
Language
English
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Publication information
Publisher
National Academy of Sciences
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Scope and Contents
Contents
Key mitochondrial functions such as ATP production, Ca2+ uptake and release, and substrate accumulation depend on the proton electrochemical gradient (ΔμH⁺) across the inner membrane. Although several drugs can modulate ΔμH⁺, their effects are hardly reversible, and lack cellular specificity and spatial resolution. Although channelrhodopsins are wi...
Alternative Titles
Full title
Optogenetic control of mitochondrial metabolism and Ca2+ signaling by mitochondria-targeted opsins
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5495261
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5495261
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1703623114
