Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory
Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Metabolic production of acetyl coenzyme A (acetyl-CoA) is linked to histone acetylation and gene regulation, but the precise mechanisms of this process are largely unknown. Here we show that the metabolic enzyme acetyl-CoA synthetase 2 (ACSS2) directly regulates histone acetylation in neurons and spatial memory in mammals. In a neuronal cell cultur...
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Full title
Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5505514
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5505514
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature22405
