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Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without n...

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Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without n...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5508040

Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss

About this item

Full title

Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss

Author / Creator

Schludi, Martin H. , Becker, Lore , Garrett, Lillian , Gendron, Tania F. , Zhou, Qihui , Schreiber, Franziska , Popper, Bastian , Dimou, Leda , Strom, Tim M. , Winkelmann, Juliane , von Thaden, Anne , Rentzsch, Kristin , May, Stephanie , Michaelsen, Meike , Schwenk, Benjamin M. , Tan, Jing , Schoser, Benedikt , Dieterich, Marianne , Petrucelli, Leonard , Hölter, Sabine M. , Wurst, Wolfgang , Fuchs, Helmut , Gailus-Durner, Valerie , de Angelis, Martin Hrabe , Klopstock, Thomas , Arzberger, Thomas and Edbauer, Dieter

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

Journal title

Acta neuropathologica, 2017-08, Vol.134 (2), p.241-254

Language

English

Formats

Articles

Publication information

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

Subjects

Subjects and topics

More information

Scope and Contents

Contents

Translation of the expanded (ggggcc)
n
repeat in
C9orf72
patients with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) causes abundant poly-GA inclusions. To elucidate their role in pathogenesis, we generated transgenic mice expressing codon-modified (GA)
149
conjugated with cyan fluorescent protein (CFP). Tr...

Alternative Titles

Full title

Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss

Authors, Artists and Contributors

Author / Creator

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5508040

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5508040

Other Identifiers

ISSN

0001-6322

E-ISSN

1432-0533

DOI

10.1007/s00401-017-1711-0

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