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ArticlesPeer ReviewedFull Text
Alpha-Synuclein defects autophagy by impairing SNAP29-mediated autophagosome-lysosome fusion
Author / Creator:Tang, Qilin ; Gao, Pan ; Arzberger, Thomas ; Höllerhage, Matthias ; Herms, Jochen ; Höglinger, Günter ; Koeglsperger, Thomas
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2021-09, Vol.12 (10), p.854-854, Article 854
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Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations
Author / Creator:Mackenzie, Ian R. ; Arzberger, Thomas ; Kremmer, Elisabeth ; Troost, Dirk ; Lorenzl, Stefan ; Mori, Kohji ; Weng, Shih-Ming ; Haass, Christian ; Kretzschmar, Hans A. ; Edbauer, Dieter ; Neumann, Manuela
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2013-12, Vol.126 (6), p.859-879
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C9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration
Author / Creator:May, Stephanie ; Hornburg, Daniel ; Schludi, Martin H. ; Arzberger, Thomas ; Rentzsch, Kristin ; Schwenk, Benjamin M. ; Grässer, Friedrich A. ; Mori, Kohji ; Kremmer, Elisabeth ; Banzhaf-Strathmann, Julia ; Mann, Matthias ; Meissner, Felix ; Edbauer, Dieter
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2014-10, Vol.128 (4), p.485-503
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Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry
Author / Creator:Braak, Heiko ; Alafuzoff, Irina ; Arzberger, Thomas ; Kretzschmar, Hans ; Del Tredici, Kelly
Publisher:Germany: Springer Nature B.V
Journal title:Acta neuropathologica, 2006-10, Vol.112 (4), p.389-404
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Distribution of dipeptide repeat proteins in cellular models and C9orf72 mutation cases suggests link to transcriptional silencing
Author / Creator:Schludi, Martin H. ; May, Stephanie ; Grässer, Friedrich A. ; Rentzsch, Kristin ; Kremmer, Elisabeth ; Küpper, Clemens ; Klopstock, Thomas ; Arzberger, Thomas ; Edbauer, Dieter
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2015-10, Vol.130 (4), p.537-555
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In situ architecture of neuronal α-Synuclein inclusions
Author / Creator:Trinkaus, Victoria A. ; Riera-Tur, Irene ; Martínez-Sánchez, Antonio ; Bäuerlein, Felix J. B. ; Guo, Qiang ; Arzberger, Thomas ; Baumeister, Wolfgang ; Dudanova, Irina ; Hipp, Mark S. ; Hartl, F. Ulrich ; Fernández-Busnadiego, Rubén
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-04, Vol.12 (1), p.2110-2110, Article 2110
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Poly-glycine–alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3
Author / Creator:Nihei, Yoshihiro ; Mori, Kohji ; Werner, Georg ; Arzberger, Thomas ; Zhou, Qihui ; Khosravi, Barham ; Japtok, Julia ; Hermann, Andreas ; Sommacal, Andreas ; Weber, Markus ; Kamp, Frits ; Nuscher, Brigitte ; Edbauer, Dieter ; Haass, Christian
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2020-01, Vol.139 (1), p.99-118
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DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex
Author / Creator:Gasparoni, Gilles ; Bultmann, Sebastian ; Lutsik, Pavlo ; Kraus, Theo F J ; Sordon, Sabrina ; Vlcek, Julia ; Dietinger, Vanessa ; Steinmaurer, Martina ; Haider, Melanie ; Mulholland, Christopher B ; Arzberger, Thomas ; Roeber, Sigrun ; Riemenschneider, Matthias ; Kretzschmar, Hans A ; Giese, Armin ; Leonhardt, Heinrich ; Walter, Jörn
Publisher:England: BioMed Central Ltd
Journal title:Epigenetics & chromatin, 2018-07, Vol.11 (1), p.41-41, Article 41
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CADASIL brain vessels show a HTRA1 loss-of-function profile
Author / Creator:Zellner, Andreas ; Scharrer, Eva ; Arzberger, Thomas ; Oka, Chio ; Domenga-Denier, Valérie ; Joutel, Anne ; Lichtenthaler, Stefan F. ; Müller, Stephan A. ; Dichgans, Martin ; Haffner, Christof
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2018-07, Vol.136 (1), p.111-125
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Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis
Author / Creator:Götzl, Julia K. ; Mori, Kohji ; Damme, Markus ; Fellerer, Katrin ; Tahirovic, Sabina ; Kleinberger, Gernot ; Janssens, Jonathan ; van der Zee, Julie ; Lang, Christina M. ; Kremmer, Elisabeth ; Martin, Jean-Jacques ; Engelborghs, Sebastiaan ; Kretzschmar, Hans A. ; Arzberger, Thomas ; Van Broeckhoven, Christine ; Haass, Christian ; Capell, Anja
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2014-06, Vol.127 (6), p.845-860
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Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss
Author / Creator:Schludi, Martin H. ; Becker, Lore ; Garrett, Lillian ; Gendron, Tania F. ; Zhou, Qihui ; Schreiber, Franziska ; Popper, Bastian ; Dimou, Leda ; Strom, Tim M. ; Winkelmann, Juliane ; von Thaden, Anne ; Rentzsch, Kristin ; May, Stephanie ; Michaelsen, Meike ; Schwenk, Benjamin M. ; Tan, Jing ; Schoser, Benedikt ; Dieterich, Marianne ; Petrucelli, Leonard ; Hölter, Sabine M. ; Wurst, Wolfgang ; Fuchs, Helmut ; Gailus-Durner, Valerie ; de Angelis, Martin Hrabe ; Klopstock, Thomas ; Arzberger, Thomas ; Edbauer, Dieter
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2017-08, Vol.134 (2), p.241-254
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PERK activation mitigates tau pathology in vitro and in vivo
Author / Creator:Bruch, Julius ; Xu, Hong ; Rösler, Thomas W ; De Andrade, Anderson ; Kuhn, Peer‐Hendrik ; Lichtenthaler, Stefan F ; Arzberger, Thomas ; Winklhofer, Konstanze F ; Müller, Ulrich ; Höglinger, Günter U
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2017-03, Vol.9 (3), p.371-384
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Active poly‐GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model
Author / Creator:Zhou, Qihui ; Mareljic, Nikola ; Michaelsen, Meike ; Parhizkar, Samira ; Heindl, Steffanie ; Nuscher, Brigitte ; Farny, Daniel ; Czuppa, Mareike ; Schludi, Carina ; Graf, Alexander ; Krebs, Stefan ; Blum, Helmut ; Feederle, Regina ; Roth, Stefan ; Haass, Christian ; Arzberger, Thomas ; Liesz, Arthur ; Edbauer, Dieter
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2020-02, Vol.12 (2), p.e10919-n/a
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Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice
Author / Creator:Schön, Christian ; Hoffmann, Nadine A ; Ochs, Simon M ; Burgold, Steffen ; Filser, Severin ; Steinbach, Sonja ; Seeliger, Mathias W ; Arzberger, Thomas ; Goedert, Michel ; Kretzschmar, Hans A ; Schmidt, Boris ; Herms, Jochen
Publisher:United States: Public Library of Science
Journal title:PloS one, 2012-12, Vol.7 (12), p.e53547-e53547
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Antibodies inhibit transmission and aggregation of C9orf72 poly‐GA dipeptide repeat proteins
Author / Creator:Zhou, Qihui ; Lehmer, Carina ; Michaelsen, Meike ; Mori, Kohji ; Alterauge, Dominik ; Baumjohann, Dirk ; Schludi, Martin H ; Greiling, Johanna ; Farny, Daniel ; Flatley, Andrew ; Feederle, Regina ; May, Stephanie ; Schreiber, Franziska ; Arzberger, Thomas ; Kuhm, Christoph ; Klopstock, Thomas ; Hermann, Andreas ; Haass, Christian ; Edbauer, Dieter
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2017-05, Vol.9 (5), p.687-702
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Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS
Author / Creator:Suárez-Calvet, Marc ; Neumann, Manuela ; Arzberger, Thomas ; Abou-Ajram, Claudia ; Funk, Eva ; Hartmann, Hannelore ; Edbauer, Dieter ; Kremmer, Elisabeth ; Göbl, Christoph ; Resch, Moritz ; Bourgeois, Benjamin ; Madl, Tobias ; Reber, Stefan ; Jutzi, Daniel ; Ruepp, Marc-David ; Mackenzie, Ian R. A. ; Ansorge, Olaf ; Dormann, Dorothee ; Haass, Christian
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2016-04, Vol.131 (4), p.587-604
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Fatty acid-binding protein 5 is a functional biomarker and indicator of ferroptosis in cerebral hypoxia
Author / Creator:Peng, Hao ; Xin, Shan ; Pfeiffer, Susanne ; Müller, Constanze ; Merl-Pham, Juliane ; Hauck, Stefanie M. ; Harter, Patrick N. ; Spitzer, Daniel ; Devraj, Kavi ; Varynskyi, Borys ; Arzberger, Thomas ; Momma, Stefan ; Schick, Joel A.
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2024-04, Vol.15 (4), p.286-12, Article 286
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Generation and deposition of Aβ43 by the virtually inactive presenilin‐1 L435F mutant contradicts the presenilin loss‐of‐function hypothesis of Alzheimer's disease
Author / Creator:Kretner, Benedikt ; Trambauer, Johannes ; Fukumori, Akio ; Mielke, Janina ; Kuhn, Peer‐Hendrik ; Kremmer, Elisabeth ; Giese, Armin ; Lichtenthaler, Stefan F ; Haass, Christian ; Arzberger, Thomas ; Steiner, Harald
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2016-05, Vol.8 (5), p.458-465
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Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits
Author / Creator:Hu, Yiying ; Hruscha, Alexander ; Pan, Chenchen ; Schifferer, Martina ; Schmidt, Michael K ; Nuscher, Brigitte ; Giera, Martin ; Kostidis, Sarantos ; Burhan, Özge ; van Bebber, Frauke ; Edbauer, Dieter ; Arzberger, Thomas ; Haass, Christian ; Schmid, Bettina
Publisher:England: BioMed Central Ltd
Journal title:Molecular neurodegeneration, 2024-06, Vol.19 (1), p.50-23, Article 50
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Effects of Antemortem and Postmortem Variables on Human Brain mRNA Quality: A BrainNet Europe Study
Author / Creator:Durrenberger, Pascal F. ; Fernando, Shama ; Kashefi, Samira N. ; Ferrer, Isidro ; Hauw, Jean-Jacques ; Seilhean, Danielle ; Smith, Colin ; Walker, Robert ; Al-Sarraj, Safa ; Troakes, Claire ; Palkovits, Miklos ; Kasztner, Magdalena ; Huitinga, Inge ; Arzberger, Thomas ; Dexter, David T. ; Kretzschmar, Hans ; Reynolds, Richard
Publisher:Hagerstown, MD: American Association of Neuropathologists, Inc
Journal title:Journal of neuropathology and experimental neurology, 2010-01, Vol.69 (1), p.70-81
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Alpha-Synuclein defects autophagy by impairing SNAP29-mediated autophagosome-lysosome fusion

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Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations

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C9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration

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Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry

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Distribution of dipeptide repeat proteins in cellular models and C9orf72 mutation cases suggests link to transcriptional silencing

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In situ architecture of neuronal α-Synuclein inclusions

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Poly-glycine–alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3

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DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex

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CADASIL brain vessels show a HTRA1 loss-of-function profile

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Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis

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Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss

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PERK activation mitigates tau pathology in vitro and in vivo

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Active poly‐GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model

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Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice

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Antibodies inhibit transmission and aggregation of C9orf72 poly‐GA dipeptide repeat proteins

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Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS

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Fatty acid-binding protein 5 is a functional biomarker and indicator of ferroptosis in cerebral hypoxia

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Generation and deposition of Aβ43 by the virtually inactive presenilin‐1 L435F mutant contradicts the presenilin loss‐of‐function hypothesis of Alzheimer's disease

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Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits

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Effects of Antemortem and Postmortem Variables on Human Brain mRNA Quality: A BrainNet Europe Study

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