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Signalome-wide RNAi screen identifies GBA1 as a positive mediator of autophagic cell death

Signalome-wide RNAi screen identifies GBA1 as a positive mediator of autophagic cell death

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5520177

Signalome-wide RNAi screen identifies GBA1 as a positive mediator of autophagic cell death

About this item

Full title

Signalome-wide RNAi screen identifies GBA1 as a positive mediator of autophagic cell death

Publisher

London: Nature Publishing Group UK

Journal title

Cell death and differentiation, 2017-07, Vol.24 (7), p.1288-1302

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Activating alternative cell death pathways, including autophagic cell death, is a promising direction to overcome the apoptosis resistance observed in various cancers. Yet, whether autophagy acts as a death mechanism by over consumption of intracellular components is still controversial and remains undefined at the ultrastructural and the mechanist...

Alternative Titles

Full title

Signalome-wide RNAi screen identifies GBA1 as a positive mediator of autophagic cell death

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5520177

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5520177

Other Identifiers

ISSN

1350-9047

E-ISSN

1476-5403

DOI

10.1038/cdd.2017.80

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