Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic ta...
Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies
About this item
Full title
Author / Creator
Alvi, Muhammad A , Loughrey, Maurice B , Dunne, Philip , McQuaid, Stephen , Turkington, Richard , Fuchs, Marc-Aurel , McGready, Claire , Bingham, Victoria , Pang, Brendan , Moore, Wendy , Maxwell, Perry , Lawler, Mark , James, Jacqueline A , Murray, Graeme I , Wilson, Richard H and Salto-Tellez, Manuel
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Background:
Signet ring cell colorectal cancer (SRCCa) has a bleak prognosis. Employing molecular pathology techniques we investigated the potential of precision medicine in this disease.
Methods:
Using test (
n
=26) and validation (
n
=18) cohorts, analysis of mutations, DNA methylation and transcriptome was carried out. Micro...
Alternative Titles
Full title
Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5520517
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5520517
Other Identifiers
ISSN
0007-0920
E-ISSN
1532-1827
DOI
10.1038/bjc.2017.168
