Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegener...
Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production
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Publisher
Cham: Springer International Publishing
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Language
English
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Cham: Springer International Publishing
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Intracellular accumulation of α-synuclein (α-syn) are hallmarks of synucleinopathies, including Parkinson’s disease (PD). Exogenous addition of preformed α-syn fibrils (PFFs) into primary hippocampal neurons induced α-syn aggregation and accumulation. Likewise, intrastriatal inoculation of PFFs into mice and non-human primates generates Lewy bodies...
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Full title
Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5524146
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5524146
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ISSN
1420-682X
E-ISSN
1420-9071
DOI
10.1007/s00018-017-2541-x
