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Signalling via the osteopontin and high mobility group box-1 axis drives the fibrogenic response to...

Signalling via the osteopontin and high mobility group box-1 axis drives the fibrogenic response to...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5532463

Signalling via the osteopontin and high mobility group box-1 axis drives the fibrogenic response to liver injury

About this item

Full title

Signalling via the osteopontin and high mobility group box-1 axis drives the fibrogenic response to liver injury

Publisher

England: BMJ Publishing Group Ltd and British Society of Gastroenterology

Journal title

Gut, 2017-06, Vol.66 (6), p.1123-1137

Language

English

Formats

Publication information

Publisher

England: BMJ Publishing Group Ltd and British Society of Gastroenterology

More information

Scope and Contents

Contents

ObjectiveLiver fibrosis is associated with significant collagen-I deposition largely produced by activated hepatic stellate cells (HSCs); yet, the link between hepatocyte damage and the HSC profibrogenic response remains unclear. Here we show significant induction of osteopontin (OPN) and high-mobility group box-1 (HMGB1) in liver fibrosis. Since O...

Alternative Titles

Full title

Signalling via the osteopontin and high mobility group box-1 axis drives the fibrogenic response to liver injury

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5532463

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5532463

Other Identifiers

ISSN

0017-5749

E-ISSN

1468-3288

DOI

10.1136/gutjnl-2015-310752

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