Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development
Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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GAS2L3 is a recently identified cytoskeleton-associated protein that interacts with actin filaments and tubulin. The in vivo function of GAS2L3 in mammals remains unknown. Here, we show that mice deficient in GAS2L3 die shortly after birth because of heart failure. Mammalian cardiomyocytes lose the ability to proliferate shortly after birth, and fu...
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Full title
Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5544300
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5544300
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1703406114
