Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
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Author / Creator
Warren, Travis K. , Jordan, Robert , Lo, Michael K. , Ray, Adrian S. , Mackman, Richard L. , Soloveva, Veronica , Siegel, Dustin , Perron, Michel , Bannister, Roy , Hui, Hon C. , Larson, Nate , Strickley, Robert , Wells, Jay , Stuthman, Kelly S. , Van Tongeren, Sean A. , Garza, Nicole L. , Donnelly, Ginger , Shurtleff, Amy C. , Retterer, Cary J. , Gharaibeh, Dima , Zamani, Rouzbeh , Kenny, Tara , Eaton, Brett P. , Grimes, Elizabeth , Welch, Lisa S. , Gomba, Laura , Wilhelmsen, Catherine L. , Nichols, Donald K. , Nuss, Jonathan E. , Nagle, Elyse R. , Kugelman, Jeffrey R. , Palacios, Gustavo , Doerffler, Edward , Neville, Sean , Carra, Ernest , Clarke, Michael O. , Zhang, Lijun , Lew, Willard , Ross, Bruce , Wang, Queenie , Chun, Kwon , Wolfe, Lydia , Babusis, Darius , Park, Yeojin , Stray, Kirsten M. , Trancheva, Iva , Feng, Joy Y. , Barauskas, Ona , Xu, Yili , Wong, Pamela , Braun, Molly R. , Flint, Mike , McMullan, Laura K. , Chen, Shan-Shan , Fearns, Rachel , Swaminathan, Swami , Mayers, Douglas L. , Spiropoulou, Christina F. , Lee, William A. , Nichol, Stuart T. , Cihlar, Tomas and Bavari, Sina
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
The discovery is reported of a small molecule drug, GS-5734, which has antiviral activity against Ebola virus and other filoviruses, and is capable of providing post-exposure therapeutic protection against lethal disease in 100% of drug-treated nonhuman primates infected with Ebola virus; the drug targets viral RNA polymerase and can distribute to sanctuary sites (such as testes, eyes and brain), suggesting that it may be able to clear persistent virus infection.
A drug active against Ebola virus
These authors report the discovery of a small-molecule drug, GS-5734, which has antiviral activity against Ebola and other filoviruses, and is capable of providing post-exposure protection against Ebola virus in 100% of infected macaques tested. Now in clinical trials (
http://go.nature.com/PEW2Oi
), the drug targets the viral RNA-dependent RNA polymerase and is readily scalable for future outbreaks. GS-5734 is able to distribute to sanctuary sites for viral replication including the testes, eye and brain, offering the hope that this drug may also be able to clear recrudescent and persistent virus infection.
The most recent Ebola...
Alternative Titles
Full title
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
Authors, Artists and Contributors
Author / Creator
Jordan, Robert
Lo, Michael K.
Ray, Adrian S.
Mackman, Richard L.
Soloveva, Veronica
Siegel, Dustin
Perron, Michel
Bannister, Roy
Hui, Hon C.
Larson, Nate
Strickley, Robert
Wells, Jay
Stuthman, Kelly S.
Van Tongeren, Sean A.
Garza, Nicole L.
Donnelly, Ginger
Shurtleff, Amy C.
Retterer, Cary J.
Gharaibeh, Dima
Zamani, Rouzbeh
Kenny, Tara
Eaton, Brett P.
Grimes, Elizabeth
Welch, Lisa S.
Gomba, Laura
Wilhelmsen, Catherine L.
Nichols, Donald K.
Nuss, Jonathan E.
Nagle, Elyse R.
Kugelman, Jeffrey R.
Palacios, Gustavo
Doerffler, Edward
Neville, Sean
Carra, Ernest
Clarke, Michael O.
Zhang, Lijun
Lew, Willard
Ross, Bruce
Wang, Queenie
Chun, Kwon
Wolfe, Lydia
Babusis, Darius
Park, Yeojin
Stray, Kirsten M.
Trancheva, Iva
Feng, Joy Y.
Barauskas, Ona
Xu, Yili
Wong, Pamela
Braun, Molly R.
Flint, Mike
McMullan, Laura K.
Chen, Shan-Shan
Fearns, Rachel
Swaminathan, Swami
Mayers, Douglas L.
Spiropoulou, Christina F.
Lee, William A.
Nichol, Stuart T.
Cihlar, Tomas
Bavari, Sina
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5551389
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5551389
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature17180
