Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade
Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade
About this item
Full title
Author / Creator
Le, Dung T. , Durham, Jennifer N. , Smith, Kellie N. , Wang, Hao , Bartlett, Bjarne R. , Aulakh, Laveet K. , Lu, Steve , Kemberling, Holly , Wilt, Cara , Luber, Brandon S. , Wong, Fay , Azad, Nilofer S. , Rucki, Agnieszka A. , Laheru, Dan , Donehower, Ross , Zaheer, Atif , Fisher, George A. , Crocenzi, Todd S. , Lee, James J. , Greten, Tim F. , Duffy, Austin G. , Ciombor, Kristen K. , Eyring, Aleksandra D. , Lam, Bao H. , Joe, Andrew , Kang, S. Peter , Holdhoff, Matthias , Danilova, Ludmila , Cope, Leslie , Meyer, Christian , Zhou, Shibin , Goldberg, Richard M. , Armstrong, Deborah K. , Bever, Katherine M. , Fader, Amanda N. , Taube, Janis , Housseau, Franck , Spetzler, David , Xiao, Nianqing , Pardoll, Drew M. , Papadopoulos, Nickolas , Kinzler, Kenneth W. , Eshleman, James R. , Vogelstein, Bert , Anders, Robert A. and Diaz, Luis A.
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
The genomes of cancers deficient in mismatch repair contain exceptionally high numbers of somatic mutations. In a proof-of-concept study, we previously showed that colorectal cancers with mismatch repair deficiency were sensitive to immune checkpoint blockade with antibodies to programmed death receptor–1 (PD-1). We have now expanded this study to...
Alternative Titles
Full title
Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade
Authors, Artists and Contributors
Author / Creator
Durham, Jennifer N.
Smith, Kellie N.
Wang, Hao
Bartlett, Bjarne R.
Aulakh, Laveet K.
Lu, Steve
Kemberling, Holly
Wilt, Cara
Luber, Brandon S.
Wong, Fay
Azad, Nilofer S.
Rucki, Agnieszka A.
Laheru, Dan
Donehower, Ross
Zaheer, Atif
Fisher, George A.
Crocenzi, Todd S.
Lee, James J.
Greten, Tim F.
Duffy, Austin G.
Ciombor, Kristen K.
Eyring, Aleksandra D.
Lam, Bao H.
Joe, Andrew
Kang, S. Peter
Holdhoff, Matthias
Danilova, Ludmila
Cope, Leslie
Meyer, Christian
Zhou, Shibin
Goldberg, Richard M.
Armstrong, Deborah K.
Bever, Katherine M.
Fader, Amanda N.
Taube, Janis
Housseau, Franck
Spetzler, David
Xiao, Nianqing
Pardoll, Drew M.
Papadopoulos, Nickolas
Kinzler, Kenneth W.
Eshleman, James R.
Vogelstein, Bert
Anders, Robert A.
Diaz, Luis A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5576142
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5576142
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aan6733
