Amyloid beta： structure, biology and structure-based therapeutic development
Amyloid beta： structure, biology and structure-based therapeutic development
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Amyloid beta peptide （Aβ） is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein （APP）, by β- and y-secretases. Aβ accumulation in the brain is proposed to be an early toxic event in the pathogenesis of Alzheimer＇s disease, which is the most common form of dementia associated with plaques and tangles in...
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Amyloid beta： structure, biology and structure-based therapeutic development
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5589967
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5589967
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ISSN
1671-4083
E-ISSN
1745-7254
DOI
10.1038/aps.2017.28
