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Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signalin...

Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signalin...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5617654

Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling

About this item

Full title

Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling

Publisher

United States: American Society for Clinical Investigation

Journal title

The Journal of clinical investigation, 2017-10, Vol.127 (10), p.3835-3844

Language

English

Formats

Publication information

Publisher

United States: American Society for Clinical Investigation

More information

Scope and Contents

Contents

Inadequate pancreatic β cell function underlies type 1 and type 2 diabetes mellitus. Strategies to expand functional cells have focused on discovering and controlling mechanisms that limit the proliferation of human β cells. Here, we developed an engraftment strategy to examine age-associated human islet cell replication competence and reveal mecha...

Alternative Titles

Full title

Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5617654

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5617654

Other Identifiers

ISSN

0021-9738

E-ISSN

1558-8238

DOI

10.1172/JCI91761

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