RIPK1 mediates a disease-associated microglial response in Alzheimer’s disease
RIPK1 mediates a disease-associated microglial response in Alzheimer’s disease
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Dysfunction of microglia is known to play an important role in Alzheimer’s disease (AD). Here, we investigated the role of RIPK1 in microglia mediating the pathogenesis of AD. RIPK1 is highly expressed by microglial cells in human AD brains. Using the amyloid precursor protein (APP)/presenilin 1 (PS1) transgenic mouse model, we found that inhibitio...
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Full title
RIPK1 mediates a disease-associated microglial response in Alzheimer’s disease
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5642727
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5642727
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1714175114
