Discovery of stimulation-responsive immune enhancers with CRISPR activation
Discovery of stimulation-responsive immune enhancers with CRISPR activation
About this item
Full title
Author / Creator
Simeonov, Dimitre R. , Gowen, Benjamin G. , Boontanrart, Mandy , Roth, Theodore L. , Gagnon, John D. , Mumbach, Maxwell R. , Satpathy, Ansuman T. , Lee, Youjin , Bray, Nicolas L. , Chan, Alice Y. , Lituiev, Dmytro S. , Nguyen, Michelle L. , Gate, Rachel E. , Subramaniam, Meena , Li, Zhongmei , Woo, Jonathan M. , Mitros, Therese , Ray, Graham J. , Curie, Gemma L. , Naddaf, Nicki , Chu, Julia S. , Ma, Hong , Boyer, Eric , Van Gool, Frederic , Huang, Hailiang , Liu, Ruize , Tobin, Victoria R. , Schumann, Kathrin , Daly, Mark J. , Farh, Kyle K. , Ansel, K. Mark , Ye, Chun J. , Greenleaf, William J. , Anderson, Mark S. , Bluestone, Jeffrey A. , Chang, Howard Y. , Corn, Jacob E. and Marson, Alexander
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The authors use tiled CRISPR activation for functional enhancer discovery across two autoimmunity risk loci,
CD69
and
IL2RA
, and identify elements with features of stimulus-responsive enhancers, including an
IL2RA
enhancer that harbours a fine-mapped autoimmunity risk variant.
CRISPRa mapping of enhancer functions
Enhancers...
Alternative Titles
Full title
Discovery of stimulation-responsive immune enhancers with CRISPR activation
Authors, Artists and Contributors
Author / Creator
Gowen, Benjamin G.
Boontanrart, Mandy
Roth, Theodore L.
Gagnon, John D.
Mumbach, Maxwell R.
Satpathy, Ansuman T.
Lee, Youjin
Bray, Nicolas L.
Chan, Alice Y.
Lituiev, Dmytro S.
Nguyen, Michelle L.
Gate, Rachel E.
Subramaniam, Meena
Li, Zhongmei
Woo, Jonathan M.
Mitros, Therese
Ray, Graham J.
Curie, Gemma L.
Naddaf, Nicki
Chu, Julia S.
Ma, Hong
Boyer, Eric
Van Gool, Frederic
Huang, Hailiang
Liu, Ruize
Tobin, Victoria R.
Schumann, Kathrin
Daly, Mark J.
Farh, Kyle K.
Ansel, K. Mark
Ye, Chun J.
Greenleaf, William J.
Anderson, Mark S.
Bluestone, Jeffrey A.
Chang, Howard Y.
Corn, Jacob E.
Marson, Alexander
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5675716
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5675716
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature23875
