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CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

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CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5706633

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

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London: Nature Publishing Group UK

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Contents

CMTM6 maintains PD-L1 at the plasma membrane by inhibiting its lysosome-mediated degradation and promoting its recycling.
Regulating immunity evasion
Understanding the molecular regulation of programmed death-1 ligand 1 (PD-L1) expression could help to explain the success of certain anti-tumour therapies that disrupt PD-L1-mediated tumour tol...

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CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

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Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5706633

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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5706633

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ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/nature23643

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