Pharmacological inhibition of the transcription factor PU.1 in leukemia
Pharmacological inhibition of the transcription factor PU.1 in leukemia
About this item
Full title
Author / Creator
Antony-Debré, Iléana , Paul, Ananya , Leite, Joana , Mitchell, Kelly , Kim, Hye Mi , Carvajal, Luis A , Todorova, Tihomira I , Huang, Kenneth , Kumar, Arvind , Farahat, Abdelbasset A , Bartholdy, Boris , Narayanagari, Swathi-Rao , Chen, Jiahao , Ambesi-Impiombato, Alberto , Ferrando, Adolfo A , Mantzaris, Ioannis , Gavathiotis, Evripidis , Verma, Amit , Will, Britta , Boykin, David W , Wilson, W David , Poon, Gregory Mk and Steidl, Ulrich
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
The transcription factor PU.1 is often impaired in patients with acute myeloid leukemia (AML). Here, we used AML cells that already had low PU.1 levels and further inhibited PU.1 using either RNA interference or, to our knowledge, first-in-class small-molecule inhibitors of PU.1 that we developed specifically to allosterically interfere with PU.1-c...
Alternative Titles
Full title
Pharmacological inhibition of the transcription factor PU.1 in leukemia
Authors, Artists and Contributors
Author / Creator
Paul, Ananya
Leite, Joana
Mitchell, Kelly
Kim, Hye Mi
Carvajal, Luis A
Todorova, Tihomira I
Huang, Kenneth
Kumar, Arvind
Farahat, Abdelbasset A
Bartholdy, Boris
Narayanagari, Swathi-Rao
Chen, Jiahao
Ambesi-Impiombato, Alberto
Ferrando, Adolfo A
Mantzaris, Ioannis
Gavathiotis, Evripidis
Verma, Amit
Will, Britta
Boykin, David W
Wilson, W David
Poon, Gregory Mk
Steidl, Ulrich
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5707147
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5707147
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI92504
