Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism
Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The folate-driven one-carbon (1C) cycle is a fundamental metabolic hub in cells that enables the synthesis of nucleotides and amino acids and epigenetic modifications. This cycle might also release formaldehyde, a potent protein and DNA crosslinking agent that organisms produce in substantial quantities. Here we show that supplementation with tetra...
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Full title
Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5714256
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5714256
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature23481
