Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through...
Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
γ-secretase is an intramembrane protease complex consisting of nicastrin, presenilin-1/2, APH-1a/b, and Pen-2. Hydrolysis of the 99-residue transmembrane fragment of amyloid precursor protein (APP-C99) by γ-secretase produces β-amyloid (Aβ) peptides. Pathogenic mutations in PSEN1 and PSEN2, which encode the catalytic subunit presenilin-1/2 of γ-sec...
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Full title
Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5715776
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5715776
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ISSN
0027-8424,1091-6490
E-ISSN
1091-6490
DOI
10.1073/pnas.1713605114
