Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosu...
Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden
About this item
Full title
Author / Creator
Stone, Meredith L. , Chiappinelli, Katherine B. , Li, Huili , Murphy, Lauren M. , Travers, Meghan E. , Topper, Michael J. , Mathios, Dimitrios , Lim, Michael , Shih, Ie-Ming , Wang, Tian-Li , Hung, Chien-Fu , Bhargava, Vipul , Wiehagen, Karla R. , Cowley, Glenn S. , Bachman, Kurtis E. , Strick, Reiner , Strissel, Pamela L. , Baylin, Stephen B. and Zahnow, Cynthia A.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Ovarian cancer is the most lethal of all gynecological cancers, and there is an urgent unmet need to develop new therapies. Epithelial ovarian cancer (EOC) is characterized by an immune suppressive microenvironment, and response of ovarian cancers to immune therapies has thus far been disappointing. We now find, in a mouse model of EOC, that clinic...
Alternative Titles
Full title
Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden
Authors, Artists and Contributors
Author / Creator
Chiappinelli, Katherine B.
Li, Huili
Murphy, Lauren M.
Travers, Meghan E.
Topper, Michael J.
Mathios, Dimitrios
Lim, Michael
Shih, Ie-Ming
Wang, Tian-Li
Hung, Chien-Fu
Bhargava, Vipul
Wiehagen, Karla R.
Cowley, Glenn S.
Bachman, Kurtis E.
Strick, Reiner
Strissel, Pamela L.
Baylin, Stephen B.
Zahnow, Cynthia A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5754782
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5754782
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1712514114
