β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease
β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease
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Author / Creator
Mittal, Shuchi , Bjørnevik, Kjetil , Im, Doo Soon , Flierl, Adrian , Dong, Xianjun , Locascio, Joseph J. , Abo, Kristine M. , Long, Elizabeth , Jin, Ming , Xu, Bing , Xiang, Yang K. , Rochet, Jean-Christophe , Engeland, Anders , Rizzu, Patrizia , Heutink, Peter , Bartels, Tim , Selkoe, Dennis J. , Caldarone, Barbara J. , Glicksman, Marcie A. , Khurana, Vikram , Schüle, Birgitt , Park, David S. , Riise, Trond and Scherzer, Clemens R.
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
United States: American Association for the Advancement of Science
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More information
Scope and Contents
Contents
Copy number mutations implicate excess production of α-synuclein as a possibly causative factor in Parkinson’s disease (PD). Using an unbiased screen targeting endogenous gene expression, we discovered that the β2-adrenoreceptor (β2AR) is a regulator of the α-synuclein gene (SNCA). β2AR ligands modulate SNCA transcription through histone 3 lysine 2...
Alternative Titles
Full title
β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease
Authors, Artists and Contributors
Author / Creator
Bjørnevik, Kjetil
Im, Doo Soon
Flierl, Adrian
Dong, Xianjun
Locascio, Joseph J.
Abo, Kristine M.
Long, Elizabeth
Jin, Ming
Xu, Bing
Xiang, Yang K.
Rochet, Jean-Christophe
Engeland, Anders
Rizzu, Patrizia
Heutink, Peter
Bartels, Tim
Selkoe, Dennis J.
Caldarone, Barbara J.
Glicksman, Marcie A.
Khurana, Vikram
Schüle, Birgitt
Park, David S.
Riise, Trond
Scherzer, Clemens R.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5761666
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5761666
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aaf3934
