Single-cell RNA-sequencing resolves self-antigen expression during mTEC development
Single-cell RNA-sequencing resolves self-antigen expression during mTEC development
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Publisher
London: Nature Publishing Group
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English
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London: Nature Publishing Group
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Contents
The crucial capability of T cells for discrimination between self and non-self peptides is based on negative selection of developing thymocytes by medullary thymic epithelial cells (mTECs). The mTECs purge autoreactive T cells by expression of cell-type specific genes referred to as tissue-restricted antigens (TRAs). Although the autoimmune regulat...
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Single-cell RNA-sequencing resolves self-antigen expression during mTEC development
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5766627
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5766627
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-19100-4
