mRNA 3′ uridylation and poly(A) tail length sculpt the mammalian maternal transcriptome
mRNA 3′ uridylation and poly(A) tail length sculpt the mammalian maternal transcriptome
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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TUT4 and TUT7 mediate 3′ uridylation of mRNA transcripts, preferentially those with short poly(A) tails; in the absence of TUT4 and TUT7, oocytes cannot mature and female mice are infertile.
Maternal transcriptome makers
After fertilization, early embryonic events are dictated by the maternal messenger RNAs stored in the oocyte. Dónal O'Carro...
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mRNA 3′ uridylation and poly(A) tail length sculpt the mammalian maternal transcriptome
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5768236
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5768236
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature23318
