Sirt2‐BubR1 acetylation pathway mediates the effects of advanced maternal age on oocyte quality
Sirt2‐BubR1 acetylation pathway mediates the effects of advanced maternal age on oocyte quality
About this item
Full title
Author / Creator
Qiu, Danhong , Hou, Xiaojing , Han, Longsen , Li, Xiaoyan , Ge, Juan and Wang, Qiang
Publisher
England: John Wiley & Sons, Inc
Journal title
Language
English
Formats
Publication information
Publisher
England: John Wiley & Sons, Inc
Subjects
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Scope and Contents
Contents
Summary
The level of Sirt2 protein is reduced in oocytes from aged mice, while exogenous expression of Sirt2 could ameliorate the maternal age‐associated meiotic defects. To date, the underlying mechanism remains unclear. Here, we confirmed that specific depletion of Sirt2 disrupts maturational progression and spindle/chromosome organization in...
Alternative Titles
Full title
Sirt2‐BubR1 acetylation pathway mediates the effects of advanced maternal age on oocyte quality
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5770883
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5770883
Other Identifiers
ISSN
1474-9718
E-ISSN
1474-9726
DOI
10.1111/acel.12698
