Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression
Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression
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Author / Creator
Lin, Heng , Wei, Shuang , Hurt, Elaine M , Green, Michael D , Zhao, Lili , Vatan, Linda , Szeliga, Wojciech , Herbst, Ronald , Harms, Paul W , Fecher, Leslie A , Vats, Pankaj , Chinnaiyan, Arul M , Lao, Christopher D , Lawrence, Theodore S , Wicha, Max , Hamanishi, Junzo , Mandai, Masaki , Kryczek, Ilona and Zou, Weiping
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Scope and Contents
Contents
Programmed death-1 receptor (PD-L1, B7-H1) and programmed cell death protein 1 (PD-1) pathway blockade is a promising therapy for treating cancer. However, the mechanistic contribution of host and tumor PD-L1 and PD-1 signaling to the therapeutic efficacy of PD-L1 and PD-1 blockade remains elusive. Here, we evaluated 3 tumor-bearing mouse models th...
Alternative Titles
Full title
Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5785251
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5785251
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI96113
