Chromosomal instability drives metastasis through a cytosolic DNA response
Chromosomal instability drives metastasis through a cytosolic DNA response
About this item
Full title
Author / Creator
Bakhoum, Samuel F. , Ngo, Bryan , Laughney, Ashley M. , Cavallo, Julie-Ann , Murphy, Charles J. , Ly, Peter , Shah, Pragya , Sriram, Roshan K. , Watkins, Thomas B. K. , Taunk, Neil K. , Duran, Mercedes , Pauli, Chantal , Shaw, Christine , Chadalavada, Kalyani , Rajasekhar, Vinagolu K. , Genovese, Giulio , Venkatesan, Subramanian , Birkbak, Nicolai J. , McGranahan, Nicholas , Lundquist, Mark , LaPlant, Quincey , Healey, John H. , Elemento, Olivier , Chung, Christine H. , Lee, Nancy Y. , Imielenski, Marcin , Nanjangud, Gouri , Pe’er, Dana , Cleveland, Don W. , Powell, Simon N. , Lammerding, Jan , Swanton, Charles and Cantley, Lewis C.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Chromosomal instability is a hallmark of cancer that results from ongoing errors in chromosome segregation during mitosis. Although chromosomal instability is a major driver of tumour evolution, its role in metastasis has not been established. Here we show that chromosomal instability promotes metastasis by sustaining a tumour cell-autonomous respo...
Alternative Titles
Full title
Chromosomal instability drives metastasis through a cytosolic DNA response
Authors, Artists and Contributors
Author / Creator
Ngo, Bryan
Laughney, Ashley M.
Cavallo, Julie-Ann
Murphy, Charles J.
Ly, Peter
Shah, Pragya
Sriram, Roshan K.
Watkins, Thomas B. K.
Taunk, Neil K.
Duran, Mercedes
Pauli, Chantal
Shaw, Christine
Chadalavada, Kalyani
Rajasekhar, Vinagolu K.
Genovese, Giulio
Venkatesan, Subramanian
Birkbak, Nicolai J.
McGranahan, Nicholas
Lundquist, Mark
LaPlant, Quincey
Healey, John H.
Elemento, Olivier
Chung, Christine H.
Lee, Nancy Y.
Imielenski, Marcin
Nanjangud, Gouri
Pe’er, Dana
Cleveland, Don W.
Powell, Simon N.
Lammerding, Jan
Swanton, Charles
Cantley, Lewis C.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5785464
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5785464
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature25432
