The Effects of 2′-O-Methoxyethyl Oligonucleotides on Renal Function in Humans
The Effects of 2′-O-Methoxyethyl Oligonucleotides on Renal Function in Humans
About this item
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Author / Creator
Publisher
United States: Mary Ann Liebert, Inc
Journal title
Language
English
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Publication information
Publisher
United States: Mary Ann Liebert, Inc
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Scope and Contents
Contents
Systemically administered 2′-
O
-methoxyethyl (2′MOE) antisense oligonucleotides (ASOs) accumulate in the kidney and metabolites are cleared in urine. The effects of eleven 2′MOE ASOs on renal function were assessed in 2,435 patients from 32 phase 2 and phase 3 trials. The principle analysis was on data from 28 randomized placebo-controlled t...
Alternative Titles
Full title
The Effects of 2′-O-Methoxyethyl Oligonucleotides on Renal Function in Humans
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5790433
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5790433
Other Identifiers
ISSN
2159-3337
E-ISSN
2159-3345
DOI
10.1089/nat.2017.0693
