Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijackin...
Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking
About this item
Full title
Author / Creator
Weischenfeldt, Joachim , Dubash, Taronish , Drainas, Alexandros P , Mardin, Balca R , Chen, Yuanyuan , Stütz, Adrian M , Waszak, Sebastian M , Bosco, Graziella , Halvorsen, Ann Rita , Raeder, Benjamin , Efthymiopoulos, Theocharis , Erkek, Serap , Siegl, Christine , Brenner, Hermann , Brustugun, Odd Terje , Dieter, Sebastian M , Northcott, Paul A , Petersen, Iver , Pfister, Stefan M , Schneider, Martin , Solberg, Steinar K , Thunissen, Erik , Weichert, Wilko , Zichner, Thomas , Thomas, Roman , Peifer, Martin , Helland, Aslaug , Ball, Claudia R , Jechlinger, Martin , Sotillo, Rocio , Glimm, Hanno and Korbel, Jan O
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Hanno Glimm, Jan Korbel and colleagues present a computational framework called
cis
expression structural alteration mapping (CESAM), which they use to identify somatic copy-number alterations affecting
cis
-regulatory elements in cancer. They find that enhancer hijacking leads to overexpression of
IRS4
and
IGF2
in cancer.
Alternative Titles
Full title
Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking
Authors, Artists and Contributors
Author / Creator
Dubash, Taronish
Drainas, Alexandros P
Mardin, Balca R
Chen, Yuanyuan
Stütz, Adrian M
Waszak, Sebastian M
Bosco, Graziella
Halvorsen, Ann Rita
Raeder, Benjamin
Efthymiopoulos, Theocharis
Erkek, Serap
Siegl, Christine
Brenner, Hermann
Brustugun, Odd Terje
Dieter, Sebastian M
Northcott, Paul A
Petersen, Iver
Pfister, Stefan M
Schneider, Martin
Solberg, Steinar K
Thunissen, Erik
Weichert, Wilko
Zichner, Thomas
Thomas, Roman
Peifer, Martin
Helland, Aslaug
Ball, Claudia R
Jechlinger, Martin
Sotillo, Rocio
Glimm, Hanno
Korbel, Jan O
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5791882
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5791882
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.3722
