Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease
Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease
About this item
Full title
Author / Creator
Dewey, Frederick E , Gusarova, Viktoria , Dunbar, Richard L , O’Dushlaine, Colm , Schurmann, Claudia , Gottesman, Omri , McCarthy, Shane , Van Hout, Cristopher V , Bruse, Shannon , Dansky, Hayes M , Leader, Joseph B , Murray, Michael F , Ritchie, Marylyn D , Kirchner, H. Lester , Habegger, Lukas , Lopez, Alex , Penn, John , Zhao, An , Shao, Weiping , Stahl, Neil , Murphy, Andrew J , Hamon, Sara , Bouzelmat, Aurelie , Zhang, Rick , Shumel, Brad , Pordy, Robert , Gipe, Daniel , Herman, Gary A , Sheu, Wayne H.H , Lee, I-Te , Liang, Kae-Woei , Guo, Xiuqing , Rotter, Jerome I , Chen, Yii-Der I , Kraus, William E , Shah, Svati H , Damrauer, Scott , Small, Aeron , Rader, Daniel J , Wulff, Anders Berg , Nordestgaard, Børge G , Tybjærg-Hansen, Anne , van den Hoek, Anita M , Princen, Hans M.G , Ledbetter, David H , Carey, David J , Overton, John D , Reid, Jeffrey G , Sasiela, William J , Banerjee, Poulabi , Shuldiner, Alan R , Borecki, Ingrid B , Teslovich, Tanya M , Yancopoulos, George D , Mellis, Scott J , Gromada, Jesper and Baras, Aris
Publisher
United States: Massachusetts Medical Society
Journal title
Language
English
Formats
Publication information
Publisher
United States: Massachusetts Medical Society
Subjects
More information
Scope and Contents
Contents
Loss-of-function variants in
ANGPTL3
were associated with lower plasma levels of lipids and lower rates of coronary disease. A monoclonal antibody against ANGPTL3 reduced the atherosclerotic lesion area in mice and reduced levels of triglycerides and LDL cholesterol in human volunteers.
Alternative Titles
Full title
Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease
Authors, Artists and Contributors
Author / Creator
Gusarova, Viktoria
Dunbar, Richard L
O’Dushlaine, Colm
Schurmann, Claudia
Gottesman, Omri
McCarthy, Shane
Van Hout, Cristopher V
Bruse, Shannon
Dansky, Hayes M
Leader, Joseph B
Murray, Michael F
Ritchie, Marylyn D
Kirchner, H. Lester
Habegger, Lukas
Lopez, Alex
Penn, John
Zhao, An
Shao, Weiping
Stahl, Neil
Murphy, Andrew J
Hamon, Sara
Bouzelmat, Aurelie
Zhang, Rick
Shumel, Brad
Pordy, Robert
Gipe, Daniel
Herman, Gary A
Sheu, Wayne H.H
Lee, I-Te
Liang, Kae-Woei
Guo, Xiuqing
Rotter, Jerome I
Chen, Yii-Der I
Kraus, William E
Shah, Svati H
Damrauer, Scott
Small, Aeron
Rader, Daniel J
Wulff, Anders Berg
Nordestgaard, Børge G
Tybjærg-Hansen, Anne
van den Hoek, Anita M
Princen, Hans M.G
Ledbetter, David H
Carey, David J
Overton, John D
Reid, Jeffrey G
Sasiela, William J
Banerjee, Poulabi
Shuldiner, Alan R
Borecki, Ingrid B
Teslovich, Tanya M
Yancopoulos, George D
Mellis, Scott J
Gromada, Jesper
Baras, Aris
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5800308
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5800308
Other Identifiers
ISSN
0028-4793
E-ISSN
1533-4406
DOI
10.1056/NEJMoa1612790
