Melatonin alleviates inflammation-induced apoptosis in human umbilical vein endothelial cells via su...
Melatonin alleviates inflammation-induced apoptosis in human umbilical vein endothelial cells via suppression of Ca²⁺-XO-ROS-Drp1-mitochondrial fission axis by activation of AMPK/SERCA2a pathway
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Author / Creator
Cui, Jiasen , Li, Zeng , Zhuang, Shunjiu , Qi, Shaohong , Li, Li , Zhou, Junwen , Zhang, Wan and Zhao, Yun
Publisher
Dordrecht: Springer
Journal title
Language
English
Formats
Publication information
Publisher
Dordrecht: Springer
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Scope and Contents
Contents
Endothelia inflammation damage is vital to the development and progression of chronic venous disease. In the present study, we explored the protective effect of melatonin on endothelia apoptosis induced by LPS, particularly focusing on the mitochondrial fission. We demonstrated that human umbilical vein endothelial cells (HUVEC) subjected to LPS fo...
Alternative Titles
Full title
Melatonin alleviates inflammation-induced apoptosis in human umbilical vein endothelial cells via suppression of Ca²⁺-XO-ROS-Drp1-mitochondrial fission axis by activation of AMPK/SERCA2a pathway
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5823809
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5823809
Other Identifiers
ISSN
1355-8145
E-ISSN
1466-1268
DOI
10.1007/s12192-017-0841-6
