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Melatonin alleviates inflammation-induced apoptosis in human umbilical vein endothelial cells via su...

Melatonin alleviates inflammation-induced apoptosis in human umbilical vein endothelial cells via su...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5823809

Melatonin alleviates inflammation-induced apoptosis in human umbilical vein endothelial cells via suppression of Ca²⁺-XO-ROS-Drp1-mitochondrial fission axis by activation of AMPK/SERCA2a pathway

About this item

Full title

Melatonin alleviates inflammation-induced apoptosis in human umbilical vein endothelial cells via suppression of Ca²⁺-XO-ROS-Drp1-mitochondrial fission axis by activation of AMPK/SERCA2a pathway

Publisher

Dordrecht: Springer

Journal title

Cell stress & chaperones, 2018-03, Vol.23 (2), p.281-293

Language

English

Formats

Publication information

Publisher

Dordrecht: Springer

More information

Scope and Contents

Contents

Endothelia inflammation damage is vital to the development and progression of chronic venous disease. In the present study, we explored the protective effect of melatonin on endothelia apoptosis induced by LPS, particularly focusing on the mitochondrial fission. We demonstrated that human umbilical vein endothelial cells (HUVEC) subjected to LPS fo...

Alternative Titles

Full title

Melatonin alleviates inflammation-induced apoptosis in human umbilical vein endothelial cells via suppression of Ca²⁺-XO-ROS-Drp1-mitochondrial fission axis by activation of AMPK/SERCA2a pathway

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5823809

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5823809

Other Identifiers

ISSN

1355-8145

E-ISSN

1466-1268

DOI

10.1007/s12192-017-0841-6

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