Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disea...
Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Asparagine endopeptidase (AEP) cleaves human α-synuclein at Asn103, yielding a fragment with higher aggregation propensity than that of the full-length protein. Truncated α-synuclein is also more neurotoxic and leads to dopaminergic neuronal loss and motor impairments in mice.
Aggregated forms of α-synuclein play a crucial role in the pathogenes...
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Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5871868
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5871868
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb.3433
