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Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5884449

Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

About this item

Full title

Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

Publisher

London: Nature Publishing Group UK

Journal title

Nature (London), 2017-11, Vol.551 (7680), p.340-345

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

IgA
+
B cells expressing programmed death ligand 1 (PD-L1) and interleukin 10 accumulate in the inflamed livers of humans and mice with non-alcoholic fatty liver disease where they promote the progression to hepatocellular carcinoma by limiting the local activation of PD-1-expressing CD8
+
T cells.
The role of adaptive immunity in ea...

Alternative Titles

Full title

Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5884449

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5884449

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/nature24302

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