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ArticlesPeer ReviewedFull Text
Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity
Author / Creator:Shalapour, Shabnam ; Lin, Xue-Jia ; Bastian, Ingmar N. ; Brain, John ; Burt, Alastair D. ; Aksenov, Alexander A. ; Vrbanac, Alison F. ; Li, Weihua ; Perkins, Andres ; Matsutani, Takaji ; Zhong, Zhenyu ; Dhar, Debanjan ; Navas-Molina, Jose A. ; Xu, Jun ; Loomba, Rohit ; Downes, Michael ; Yu, Ruth T. ; Evans, Ronald M. ; Dorrestein, Pieter C. ; Knight, Rob ; Benner, Christopher ; Anstee, Quentin M. ; Karin, Michael
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2017-11, Vol.551 (7680), p.340-345
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BRD4 is a novel therapeutic target for liver fibrosis
Author / Creator:Ding, Ning ; Hah, Nasun ; Yu, Ruth T. ; Sherman, Mara H. ; Benner, Chris ; Leblanc, Mathias ; He, Mingxiao ; Liddle, Christopher ; Downes, Michael ; Evans, Ronald M.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-12, Vol.112 (51), p.15713-15718
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Depletion of fat-resident Treg cells prevents age-associated insulin resistance
Author / Creator:Bapat, Sagar P. ; Myoung Suh, Jae ; Fang, Sungsoon ; Liu, Sihao ; Zhang, Yang ; Cheng, Albert ; Zhou, Carmen ; Liang, Yuqiong ; LeBlanc, Mathias ; Liddle, Christopher ; Atkins, Annette R. ; Yu, Ruth T. ; Downes, Michael ; Evans, Ronald M. ; Zheng, Ye
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2015-12, Vol.528 (7580), p.137-141
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β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity
Author / Creator:Valentine, Joseph M. ; Ahmadian, Maryam ; Keinan, Omer ; Abu-Odeh, Mohammad ; Zhao, Peng ; Zhou, Xin ; Keller, Mark P. ; Gao, Hui ; Yu, Ruth T. ; Liddle, Christopher ; Downes, Michael ; Zhang, Jin ; Lusis, Aldons J. ; Attie, Alan D. ; Evans, Ronald M. ; Rydén, Mikael ; Saltiel, Alan R.
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2022-01, Vol.132 (2)
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ArticlesPeer ReviewedFull Text
Inflammation-sensitive super enhancers form domains of coordinately regulated enhancer RNAs
Author / Creator:Hah, Nasun ; Benner, Chris ; Chong, Ling-Wa ; Yu, Ruth T. ; Downes, Michael ; Evans, Ronald M.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-01, Vol.112 (3), p.E297-E302
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Stromal cues regulate the pancreatic cancer epigenome and metabolome
Author / Creator:Sherman, Mara H. ; Yu, Ruth T. ; Tseng, Tiffany W. ; Sousa, Cristovao M. ; Liu, Sihao ; Truitt, Morgan L. ; He, Nanhai ; Ding, Ning ; Liddle, Christopher ; Atkins, Annette R. ; Leblanc, Mathias ; Collisson, Eric A. ; Asara, John M. ; Kimmelman, Alec C. ; Downes, Michael ; Evans, Ronald M.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-01, Vol.114 (5), p.1129-1134
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ArticlesPeer ReviewedFull Text
Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer
Author / Creator:Suh, Jae Myoung ; Jonker, Johan W. ; Ahmadian, Maryam ; Goetz, Regina ; Lackey, Denise ; Osborn, Olivia ; Huang, Zhifeng ; Liu, Weilin ; Yoshihara, Eiji ; van Dijk, Theo H. ; Havinga, Rick ; Fan, Weiwei ; Yin, Yun-Qiang ; Yu, Ruth T. ; Liddle, Christopher ; Atkins, Annette R. ; Olefsky, Jerrold M. ; Mohammadi, Moosa ; Downes, Michael ; Evans, Ronald M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2014-09, Vol.513 (7518), p.436-439
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The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
Author / Creator:Zhang, Yuan ; Xie, Yang ; Berglund, Eric D ; Coate, Katie Colbert ; He, Tian Teng ; Katafuchi, Takeshi ; Xiao, Guanghua ; Potthoff, Matthew J ; Wei, Wei ; Wan, Yihong ; Yu, Ruth T ; Evans, Ronald M ; Kliewer, Steven A ; Mangelsdorf, David J
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2012-10, Vol.1, p.e00065-e00065
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Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist
Author / Creator:Iwaisako, Keiko ; Haimerl, Michael ; Paik, Yong-Han ; Taura, Kojiro ; Kodama, Yuzo ; Sirlin, Claude ; Yu, Elizabeth ; Yu, Ruth T ; Downes, Michael ; Evans, Ronald M ; Brenner, David A ; Schnabl, Bernd
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2012-05, Vol.109 (21), p.E1369-E1376
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ArticlesPeer ReviewedFull Text
Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation
Author / Creator:Sun, GuoQiang ; Yu, Ruth T ; Evans, Ronald M ; Shi, Yanhong
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2007-09, Vol.104 (39), p.15282-15287
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ArticlesPeer ReviewedFull Text
Regulation of Antibacterial Defense in the Small Intestine by the Nuclear Bile Acid Receptor
Author / Creator:Inagaki, Takeshi ; Moschettat, Antonio ; Lee, Youn-Kyoung ; Peng, Li ; Zhao, Guixiang ; Downes, Michael ; Yu, Ruth T. ; Shelton, John M. ; Richardson, James A. ; Repa, Joyce J. ; Mangelsdorf, David J. ; Kliewer, Steven A.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2006-03, Vol.103 (10), p.3920-3925
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ArticlesPeer ReviewedFull Text
Inhibiting stromal Class I HDACs curbs pancreatic cancer progression
Author / Creator:Liang, Gaoyang ; Oh, Tae Gyu ; Hah, Nasun ; Tiriac, Hervé ; Shi, Yu ; Truitt, Morgan L. ; Antal, Corina E. ; Atkins, Annette R. ; Li, Yuwenbin ; Fraser, Cory ; Ng, Serina ; Pinto, Antonio F. M. ; Nelson, Dylan C. ; Estepa, Gabriela ; Bashi, Senada ; Banayo, Ester ; Dai, Yang ; Liddle, Christopher ; Yu, Ruth T. ; Hunter, Tony ; Engle, Dannielle D. ; Han, Haiyong ; Von Hoff, Daniel D. ; Downes, Michael ; Evans, Ronald M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-12, Vol.14 (1), p.7791-7791, Article 7791
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Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy
Author / Creator:Saison-Ridinger, Maya ; DelGiorno, Kathleen E. ; Zhang, Tejia ; Kraus, Annabelle ; French, Randall ; Jaquish, Dawn ; Tsui, Crystal ; Erikson, Galina ; Spike, Benjamin T. ; Shokhirev, Maxim N. ; Liddle, Christopher ; Yu, Ruth T. ; Downes, Michael ; Evans, Ronald M. ; Saghatelian, Alan ; Lowy, Andrew M. ; Wahl, Geoffrey M.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2017-12, Vol.12 (12), p.e0189051-e0189051
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ArticlesPeer ReviewedFull Text
High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice
Author / Creator:Wall, Christopher E ; Jamie Whyte ; Jae M. Suh ; Weiwei Fan ; Brett Collins ; Christopher Liddle ; Ruth T. Yu ; Annette R. Atkins ; Jane C. Naviaux ; Kefeng Li ; Andrew Taylor Bright ; William A. Alaynick ; Michael Downes ; Robert K. Naviaux ; Ronald M. Evans
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-07, Vol.112 (28), p.8714-8719
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Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis
Author / Creator:Hong, Suk-Hyun ; Fang, Sungsoon ; Lu, Benson C. ; Nofsinger, Russell ; Kawakami, Yasuhiko ; Castro, Glenda L. ; Yin, Yunqiang ; Lin, Chengqi ; Yu, Ruth T. ; Downes, Michael ; Belmonte, Juan Carlos Izpisúa ; Shilatifard, Ali ; Evans, Ronald M.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-10, Vol.115 (41), p.10381-10386
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NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection
Author / Creator:Wang, Jianrong ; He, Nanhai ; Zhang, Na ; Quan, Dexian ; Zhang, Shuo ; Zhang, Caroline ; Yu, Ruth T. ; Atkins, Annette R. ; Zhu, Ruihong ; Yang, Chunhui ; Cui, Ying ; Liddle, Christopher ; Downes, Michael ; Xiao, Hui ; Zheng, Ye ; Auwerx, Johan ; Evans, Ronald M. ; Leng, Qibin
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-10, Vol.8 (1), p.959-10, Article 959
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Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance
Author / Creator:Fang, Sungsoon ; Suh, Jae Myoung ; Atkins, Annette R ; Hong, Suk-Hyun ; Leblanc, Mathias ; Nofsinger, Russell R ; Yu, Ruth T ; Downes, Michael ; Evans, Ronald M
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2011-02, Vol.108 (8), p.3412-3417
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SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis
Author / Creator:Nofsinger, Russell R ; Li, Pingping ; Hong, Suk-Hyun ; Jonker, Johan W ; Barish, Grant D ; Ying, Hao ; Cheng, Sheue-yann ; LeBlanc, Mathias ; Xu, Wei ; Pei, Liming ; Kang, Yeon-Joo ; Nelson, Michael ; Downes, Michael ; Yu, Ruth T ; Olefsky, Jerrold M ; Lee, Chih-Hao ; Evans, Ronald M
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2008-12, Vol.105 (50), p.20021-20026
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Immune-evasive human islet-like organoids ameliorate diabetes
Author / Creator:Yoshihara, Eiji ; O’Connor, Carolyn ; Gasser, Emanuel ; Wei, Zong ; Oh, Tae Gyu ; Tseng, Tiffany W. ; Wang, Dan ; Cayabyab, Fritz ; Dai, Yang ; Yu, Ruth T. ; Liddle, Christopher ; Atkins, Annette R. ; Downes, Michael ; Evans, Ronald M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2020-10, Vol.586 (7830), p.606-611
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Metabolic control of regulatory T cell (Treg) survival and function by Lkb1
Author / Creator:He, Nanhai ; Fan, Weiwei ; Henriquez, Brian ; Yu, Ruth T. ; Atkins, Annette R. ; Liddle, Christopher ; Zheng, Ye ; Downes, Michael ; Evans, Ronald M.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-11, Vol.114 (47), p.12542-12547
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Showing 1 to 20 of 76 results

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Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

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BRD4 is a novel therapeutic target for liver fibrosis

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Depletion of fat-resident Treg cells prevents age-associated insulin resistance

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β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity

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Inflammation-sensitive super enhancers form domains of coordinately regulated enhancer RNAs

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Stromal cues regulate the pancreatic cancer epigenome and metabolome

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Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer

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The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

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Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist

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Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation

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Regulation of Antibacterial Defense in the Small Intestine by the Nuclear Bile Acid Receptor

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Inhibiting stromal Class I HDACs curbs pancreatic cancer progression

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Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy

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High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice

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Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis

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NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection

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Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance

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SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis

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Immune-evasive human islet-like organoids ameliorate diabetes

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Metabolic control of regulatory T cell (Treg) survival and function by Lkb1

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