Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase
Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase
About this item
Full title
Author / Creator
McBrayer, Samuel K. , Olenchock, Benjamin A. , DiNatale, Gabriel J. , Shi, Diana D. , Khanal, Januka , Jennings, Rebecca B. , Novak, Jesse S. , Oser, Matthew G. , Robbins, Alissa K. , Modiste, Rebecca , Bonal, Dennis , Moslehi, Javid , Bronson, Roderick T. , Neuberg, Donna , Nguyen, Quang-De , Signoretti, Sabina , Losman, Julie-Aurore and Kaelin, William G.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Inactivation of the retinoblastoma gene (RB1) product, pRB, is common in many human cancers. Targeting downstream effectors of pRB that are central to tumorigenesis is a promising strategy to block the growth of tumors harboring loss-of-function RB1 mutations. One such effector is retinoblastoma-binding protein 2 (RBP2, also called JARID1A or KDM5A...
Alternative Titles
Full title
Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase
Authors, Artists and Contributors
Author / Creator
Olenchock, Benjamin A.
DiNatale, Gabriel J.
Shi, Diana D.
Khanal, Januka
Jennings, Rebecca B.
Novak, Jesse S.
Oser, Matthew G.
Robbins, Alissa K.
Modiste, Rebecca
Bonal, Dennis
Moslehi, Javid
Bronson, Roderick T.
Neuberg, Donna
Nguyen, Quang-De
Signoretti, Sabina
Losman, Julie-Aurore
Kaelin, William G.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5910822
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5910822
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1716029115
